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FLASH GENE

Symbol

PSMC6

contributors: mct - updated : 01-07-2014

HGNC name	proteasome (prosome, macropain) 26S subunit, ATPase, 6
HGNC id	9553

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

C terminus with non-HbYX motif is essential for cellular 26 S proteasome assembly

HOMOLOGY

Homologene

FAMILY

PSM, proteasome family, triple-A family of ATPases

CATEGORY

chaperone/stress , enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm

basic FUNCTION	19/22S regulator of proteasome p42, ATPase subunit, involved in the ATP-dependent degradation of ubiquitinated proteins
	direct target of transcriptional activation domains in the 26S proteasome
	proteasome subunit enriched at telomeres and at genes transcribed by RNA polymerase III

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component 26S (prosome-macropain) of multicatalytic proteinase complex of proteasome

INTERACTION

DNA

RNA

small molecule

protein

FLCN and PSMC6 interaction may be evolutionarily conserved between flies and humans

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed tumor     PSMC6 inhibition may present a novel methodology to inhibit tumor development in Birt-Hogg-Dubé tumor

ANIMAL & CELL MODELS