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FLASH GENE
Symbol PSMC6 contributors: mct - updated : 01-07-2014
HGNC name proteasome (prosome, macropain) 26S subunit, ATPase, 6
HGNC id 9553
Location 14q22.1      Physical location : 53.173.895 - 53.194.715
Synonym name
  • 26S protease regulatory subunit S10B
  • conserved ATPase domain protein 44
  • suppressor for Gal2
  • Synonym symbol(s) CADP44, MGC12520, P44, SUG2, p42, RPT4
    DNA
    TYPE functioning gene
    STRUCTURE 20.82 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    C14orf29 14q21.3 chromosome 14 open reading frame 29 PYGL 14q21.2 phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI) MRP63P9 14q22.1 mitochondrial ribosomal protein 63 pseudogene 9 TRIM9 14q21.3 tripartite motif-containing 9 TXNDC 14q21.3 thioredoxin domain containing LOC283553 14q22.1 hypothetical LOC283553 SETP2 14 SET pseudogene 2 C14orf31 14q21.3 chromosome 14 open reading frame 31 LOC341856 14q22.1 similar to putative taste receptor HTR2 C14orf166 14q22.1 chromosome 14 open reading frame 166 NID2 14q21-q22 nidogen 2 (osteonidogen) COX5AP2 14 cytochrome c oxidase subunit Va pseudogene 2 PTGDR 14q22.1 prostaglandin D2 receptor (DP) PTGER2 14q21.2 prostaglandin E receptor 2 (subtype EP2), 53kDa KIAA1344 14q22.1 KIAA1344 DKFZp762F0713 14q22.1 hypothetical protein DKFZp762F0713 ERO1L 14q22.1 ERO1-like (S. cerevisiae) PSMC6 12q15 proteasome (prosome, macropain) 26S subunit, ATPase, 6 STYX  serine/threonine/tyrosine interacting protein GNPNAT1 14q22.1 glucosamine-phosphate N-acetyltransferase 1 PLEKHC1 14q22.1 pleckstrin homology domain containing, family C (with FERM domain) member 1 NDUFB3P3 14q22.3-q23.1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 3 DDHD1 14q21 DDHD domain containing 1 BMP4 14q22-q23 bone morphogenetic protein 4 LOC341862 14q22.1 similar to ATP synthase gamma chain, mitochondrial precursor CDKN3 14q22 cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase) CNIH 14q22.1 cornichon homolog (Drosophila) GMFB 14q22.1 glia maturation factor, beta
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 1599 - 403 - 1998 9473509
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Endocrineparathyroid   highly
    Reproductivefemale systemuterus  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C terminus with non-HbYX motif is essential for cellular 26 S proteasome assembly
  • HOMOLOGY
    Homologene
    FAMILY PSM, proteasome family, triple-A family of ATPases
    CATEGORY chaperone/stress , enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • 19/22S regulator of proteasome p42, ATPase subunit, involved in the ATP-dependent degradation of ubiquitinated proteins
  • direct target of transcriptional activation domains in the 26S proteasome
  • proteasome subunit enriched at telomeres and at genes transcribed by RNA polymerase III
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component 26S (prosome-macropain) of multicatalytic proteinase complex of proteasome
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FLCN and PSMC6 interaction may be evolutionarily conserved between flies and humans
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    tumor  
    PSMC6 inhibition may present a novel methodology to inhibit tumor development in Birt-Hogg-Dubé tumor
    ANIMAL & CELL MODELS