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Symbol ARNT contributors: mct - updated : 20-03-2015
HGNC name aryl hydrocarbon receptor nuclear translocator
HGNC id 700
Location 1q21.2      Physical location : 150.782.185 - 150.849.186
Synonym name
  • hypoxia-inducible factor 1, beta subunit
  • class E basic helix-loop-helix protein 2
  • Synonym symbol(s) DIRT, HIF1B, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2
    TYPE functioning gene
    STRUCTURE 67.06 kb     22 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    text structure several transcription start sites
    MAPPING cloned Y linked Y status confirmed
    Map cen - TSHB - D1S13 ,ARNT ,D1Z5 ,MUC1 - SPTA1 - CRP - APOA2 APOA2 - D1S104 - qter
    Authors Johnson (93)
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - splicing 2600 - - lowly in liver 2000 11129342
    21 - 4855 - 773 - 2000 11129342
    21 - 4858 - 774 - 2000 11129342
    - - 4903 - 789 - 2000 11129342
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    cell lineage
    cell lines
    at STAGE
    physiological period embryo
    Text stem cells
  • a N terminal basic helix-loop-helix (HLH) motif juxtaposed to a stretch of approximately 300AA, termed the PAS (Per - ARNT - Sim) region, to interact with several transcriptional coactivators that are required for transcriptional initiation after xenobiotic or hypoxic cues
  • a cysteine rich region
  • two PAS (per-arnt-sim) dimerization domains
  • one PAS-associated C-terminal (PAC) domain, to interact with two coiled coil coactivators, TRIP11 and CALCOCO1
  • mono polymer heteromer , dimer
    interspecies homolog to murine Arnt
    FAMILY PAS superfamily
    CATEGORY transcription factor , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • dioxin receptor translocator, activating genes involved in metabolism, angiogenesis and apoptosis
  • functions as an estrogen receptor beta-selective coactivator
  • functions in concert with RELB in a TNFRSF8-induced negative feedback mechanism
  • basic helix-loop-helix Period/ARNT/Single-minded (bHLH-PAS) protein that controls various biological pathways as part of dimeric transcriptional regulator complexes with other bHLH-PAS proteins
  • acts as a modulator to bridge the JUN/SP1 interaction and plays a role in EGF-mediated gene expression under normoxic conditions
  • important role for ARNT in anaplerosis, and it may play a critical role in maintaining normal secretion competence of pancreatic beta-cells
  • important regulator of hepatocellular carcinoma growth and metastasis
  • regulates glucose uptake, mitochondrial gene expression, and vascular permeability to control adipose mass and function, providing a target for obesity therapy
  • dioxin-independent co-activator/co-repressor function for ARNT in estrogen signalling
  • redistribution of ARNT from nucleus to cytoplasm involved in suppression of the hypoxia inducible factor-1 function
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription
    a component
  • complexing with HIF1A and HIF2A
  • obligate heterodimeric partner for bHLH-PAS proteins involved in sensing and coordinating transcriptional responses to xenobiotics, hypoxia, and developmental pathways
  • forms a heterodimer with aryl hydrocarbon receptor or HIF1A to mediate biological responses to xenobiotic exposure and hypoxia
    DNA DNA binding
    small molecule
  • TNFRSF8-interacting protein that modulated the activity of the RELB subunit of the transcription factor nuclear factor kappaB (NF-kappaB)
  • binds to other basic helix-loop-helix Per/ARNT/Sim (bHLH-PAS) proteins to form functional transcriptional complexes in order to regulate specific biological pathways
  • MAGED1 binds and positively regulates the transcriptional activity of family members SIM1, SIM2, NPAS4 and ARNT2, but does not interact with AHR, HIF1A and ARNT
  • ARNT plays an important role in the modulation of the dual functions of the AHR
  • cell & other
    inhibited by cardiovascular basic helix loop helix factor 1,(CHF1) in mouse
    MIR24 (MIR-24-dependent down-regulation of ARNT decreased the expression of its downstream genes such as CYP1A1 and carbonic anhydrase IX)
    repressed by by hydrogen peroxide or reactive oxygen species
    Other NFKB directly regulates ARNT mRNA and protein
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    fused with ETV6 in t(1;12)(q21;p13) in acute myeloblastic leukemia
    tumoral fusion      
    with ETV6in t(1;12)(q21;p13), in T-cell lymphoblastic leukemia (T-ALL)
    Susceptibility to oral clefts in Japanese patients
    Variant & Polymorphism SNP
    Candidate gene
  • could be a promising prognostic candidate in hepatocellular carcinoma patients
  • Marker
    Therapy target