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FLASH GENE

Symbol

PSMC1

contributors: mct/npt - updated : 17-07-2008

HGNC name	proteasome (prosome, macropain) 26S subunit, ATPase, 1
HGNC id	9547

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	16.07 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 11 - 1586 49 440 - Ewing (2007)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive pharynx       highly Endocrine pancreas       highly Hearing/Equilibrium ear       highly Nervous brain       highly Reproductive female system ovary     highly Respiratory lung       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to murine Psmc1
	homolog to Drosophila Pros26.4
	homolog to C.elegans rpt.2

Homologene

FAMILY	PSM, proteasome family
	AAA ATPase family

CATEGORY

chaperone/stress , enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION

an ATPase-like subunit of the 19 S proteasome component

CELLULAR PROCESS	protein, degradation
	protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

ATPase subunit of the 26 S (prosome-macropain) multicatalytic proteinase complex of proteasome

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP

protein

interacts with HBX and PSMA7

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS