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FLASH GENE

Symbol

CCR9

contributors: mct - updated : 12-07-2007

HGNC name	chemokine (C-C motif) receptor 9
HGNC id	1610

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly Lymphoid/Immune lymph node       lowly   spleen       lowly   thymus       specific

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to rattus Ccr9 (86.5 pc)
	homolog to murine Ccr9 (85.6 pc)

Homologene

FAMILY	G protein coupled receptor superfamily (family 1)
	beta chemokine receptor family

CATEGORY

immunity/defense , receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	acting as a specific receptor for chemokine SCYA25/TECK
	transducing subsequently a signal by increasing the intracellular calcium ions level
	acting as a alternative coreceptor with CD4 for HIV-1 infection
	acting as a rhodopsin-like receptor

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

induced by

TLR2 ligands that induce CCR9 and CCR10 expression by circulating B cells and increased chemotaxis to cognate chemokines CCL25 and CCL28

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS