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FLASH GENE
Symbol GFRA3 contributors: mct/npt - updated : 07-07-2008
HGNC name GDNF family receptor alpha 3
HGNC id 4245
Location 5q31.1-q31.3      Physical location : 137.588.070 - 137.610.253
Synonym name
  • glial cell line-derived neurotrophic factor (GDNF) receptor alpha 3
  • GPI-linked receptor
    • Synonym symbol(s) GFR3, GFR-alpha-3
    DNA
    TYPE functioning gene
    STRUCTURE 22.00 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1980 44.5 400 - Wang (2006)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     stomach    
    Hearing/Equilibriumear   highly
    Nervousbrainhindbraincerebellum predominantly
     gangliaautonomic gangliasympathetic  
     spinal cord    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsensory   
    Nervousautonomous   
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
     nociceptive cell
    not specificsensory ganglia
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to GFRA1,GFRA2,GFRA4
    Homologene
    FAMILY
  • GDNFR family
    • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text anchored to the membrane by a C terminal glycosylphosphatidylinositol (GPI)-linkage
    basic FUNCTION
  • glycosylphosphatidylinositol linked cell surface receptor for artenin (ARTN) activating the RET receptor tyrosine kinase
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • artemin
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS