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FLASH GENE
Symbol S100A4 contributors: mct/pgu - updated : 16-11-2016
HGNC name S100 calcium binding protein A4
HGNC id 10494
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in bile duct adenocarcinoma with invasivenessand in colon carcinoma and liver metastases
tumoral     --over  
during the progression of prostate cancer
tumoral     --over  
in Barrett's adenocarcinomas
constitutional     --over  
in injured myocardium and promotes growth and survival of cardiac myocytes
tumoral     --over  
in colorectal carcinoma with metastasis
tumoral     --over  
by hypomethylation in the grade 3 endometrioid tumors, uterine papillary serous carcinoma, and uterine malignant mixed mllerian tumor
tumoral     --over  
is an inducer of metastasis and indicator of poor prognosis in breast cancer
constitutional     --over  
of RLN2 and S100A4 might be related to the prediction of metastasis potency and poor prognosis for osteosarcoma patients
tumoral     --over  
in pancreatic cancer
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • detection of RLN2 and S100A4 might be useful in evaluating the outcome of patients with osteosarcoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    could be used as a biomarker for prostate carcinoma progression and a novel therapeutic or chemopreventive target for prostate carcinoma treatment (suppressor of S100A4)
    cancermetastases 
    potentially valuable molecular target for cancer therapy
    cancermetastases 
    C-terminal region of S100A4 is a possible target for inhibitors of its metastatic action
    ANIMAL & CELL MODELS