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FLASH GENE
Symbol DCN contributors: mct/shn - updated : 01-05-2015
HGNC name decorin
HGNC id 2705
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide, and a dermatan sulfate chain at its N-terminus
  • a N terminal O-linked glycosylation site
  • 12 leucine-rich repeats (LRR) flanked by cysteine-rich regions; derived 26 AAs peptide Leucine Rich Repeat 5 (LRR5) inhibits multiple aspects of angiogenesis including vascular endothelial growth factor (VEGFA) stimulated migration of endothelial cells (ECs) (
  • a N-linked glycosylation site (NKSIT motifs) in the LRR region
  • one attached glycosaminoglycan chain
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to Dcn, Mus musculus
    ortholog to Dcn, Rattus norvegicus
    ortholog to dcn, Danio rerio
    ortholog to DCN, Pan troglodytes
    Homologene
    FAMILY
  • leucine-rich proteoglycan (LRR) family
  • small interstitial proteoglycans family
  • specialized collagens and SLRP family
  • small leucine-rich proteoglycans family
    • CATEGORY structural protein , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    text small cellular or pericellular matrix proteoglycan
    basic FUNCTION
  • may play a role in epithelial/mesenchymal interactions during organ development and shaping
  • affecting the rate of fibrils formation
  • involved in the differentiation of retinal glanglion cells and in suppression of tumorigenic potential of mammary tumor cells
  • playing a role in matrix assembly
  • suppressing the growth of various tumor cell lines
  • having a key role in the regulation of stromal fibril assembly, primarily regulating lateral fibril growth
  • with BGN have a coordinate and cooperative relationship in the regulation of stromal fibrillogenesis
  • can directly boost the ability of neurons to extend axons within chondroitin sulfate proteoglycans or myelin rich environments
  • plays complex roles in both normal vascular physiology and the pathogenesis of various types of vascular disorders
  • plays an important role in the highly orchestrated process of dentin mineralization
  • important role of decorin in the extracellular matrix
  • able to inhibit CTGF action inhibiting CTGF-mediated fibronectin accumulation and expression and stress fiber formation
  • small leucine-rich proteoglycan involved in regulating matrix organization and cell signaling
  • BGN and DCN may have sequential roles in the tendon response to injury
  • BGN and DCN are class I members of the small leucine-rich proteoglycan (SLRP) family that regulate collagen fibril size
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text histogenesis and organogenesis
    PATHWAY
    metabolism
    signaling
  • ITGB1-WNT7A-DCN pathway promotes proliferation and differentiation of neuroepithelial cells, and identify DCN as a novel neurogenic factor in the central nervous system
    • a component
  • small collagen-binding proteoglycan constituent of the extracellular matrix
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • pepsin-derived fragments containing the collagenous domain of C1q
  • thrombospondin
  • collagen type VI
  • heparin cofactor II
  • collagen XIV
  • TGF-beta
  • epidermal growth factor (EGF) receptor
  • group IIA phospholipase A(2)
  • microfibrillar proteins MAGP-1 and fibrillin-1
  • Wnt-1-induced secreted protein 1, WISP-1
  • biglycan
  • alpha2HS-glycoprotein, alpha2HSG
  • filamin-A
  • tumour necrosis factor-alpha, TNF-alpha
  • pulmonary surfactant protein D
  • BGN during corneal development and DCN may have a primary role in regulating fibril assembly, a function that can be fine-tuned by biglycan during early development
  • connective tissue growth factor (CTGF CCN2)
  • interacts with CTGF and regulates its biological activity, and is able to inhibit CTGF action through its LRR12
  • OTUB1 interacted with DCN (the overexpression of OTUB1 enhanced the ubiquitination and degradation of DCN in mesangial cells (MC)
  • has an impact on the biology of ITGA2B1 integrin and the vimentin intermediate filament system
    • cell & other
    REGULATION
    activated by BMP1-1 or BMP1-3 isoforms
    induced by CTGF, that induces the synthesis of its negative regulator decorin
    Other proteolytic degradation of DCN by MMP-2, MMP-3 and MMP-7
    ASSOCIATED DISORDERS
    corresponding disease(s) CSCD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in a high percentage of the follicular thyroid adenomas, follicular thyroid carcinomas, and follicular variant of papillary thyroid carcinomas
    tumoral     --low  
    in prostate cancer stroma compared to non-malignant prostate stroma
    Susceptibility
    Variant & Polymorphism
    Candidate gene certainly providing a usable biomarker for distinguishing between benign and malignant vascular tumors in patients
    Marker
    Therapy target useful as potential targets for thyroid tumor treatment
    ANIMAL & CELL MODELS
  • (Dcn(-/-) mice display a phenotype similar to that of Ehlers-Dabnlos patients