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FLASH GENE
Symbol DCN contributors: mct/shn - updated : 01-05-2015
HGNC name decorin
HGNC id 2705
Corresponding disease
CSCD congenital stroma corneal dystrophy
Location 12q21.33      Physical location : 91.539.035 - 91.576.806
Synonym name
  • bone proteoglycan II precursor
  • dermatan sulphate proteoglycans II
  • proteoglycan core protein
  • decorin proteoglycan
  • small leucine-rich protein 1B
    • Synonym symbol(s) DSPG2, PG40, PGII, PGS2, SLRR1B, CSCD, PGII,
    DNA
    TYPE functioning gene
    STRUCTURE 37.77 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   HRE
    text structure
  • promoter activity was significantly increased by activation of NR1H4
  • an imperfect inverted repeat DNA motif, IR8 (-2313TGGTCAtagtgtcaTGACCT-2294), as a likely NR1H4-responsive element that is involved in decorin regulation
    • MAPPING cloned Y linked N status confirmed
    Map cen - D12S1717 - D12S1064 - DCN -D12S351 - D12S1699 - qter
    RNA
    TRANSCRIPTS type messenger
    text multiple polyadenylation sites
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 splicing 2305 39.7 359 corneal interlamellar filaments 2008 20484579
  • preproprotein
  • encoding the same isoform a than the variant A2
    • 8 splicing 2151 39.7 359 - 2008 18638554
  • encoding the same isoform a than the variant
  • utilizing an alternative exon at the 5'UTR
    • 5 splicing 1570 - 250 - 2008 18638554
  • lacking exon 3 and 4
  • isoform b
    • 4 splicing 1456 - 212 - 2008 18638554
  • lacking exons 3,4 and 5
  • frameshift
  • isoform c
    • 3 splicing 1336 - 172 - 2008 18638554
  • lacking exons 4,5,6 and 7
  • isoform d
    • 2 splicing 1223 - 75 - 2008 18638554
  • lacking exons 3,4,5,6 and 7
  • frameshift
  • isoform e
    		•
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
    Reproductivemale systemprostate    Rattus norvegicusFetal
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Connectivebone  highly
    Connectivecartilage   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide, and a dermatan sulfate chain at its N-terminus
  • a N terminal O-linked glycosylation site
  • 12 leucine-rich repeats (LRR) flanked by cysteine-rich regions; derived 26 AAs peptide Leucine Rich Repeat 5 (LRR5) inhibits multiple aspects of angiogenesis including vascular endothelial growth factor (VEGFA) stimulated migration of endothelial cells (ECs) (
  • a N-linked glycosylation site (NKSIT motifs) in the LRR region
  • one attached glycosaminoglycan chain
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to Dcn, Mus musculus
    ortholog to Dcn, Rattus norvegicus
    ortholog to dcn, Danio rerio
    ortholog to DCN, Pan troglodytes
    Homologene
    FAMILY
  • leucine-rich proteoglycan (LRR) family
  • small interstitial proteoglycans family
  • specialized collagens and SLRP family
  • small leucine-rich proteoglycans family
    • CATEGORY structural protein , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    text small cellular or pericellular matrix proteoglycan
    basic FUNCTION
  • may play a role in epithelial/mesenchymal interactions during organ development and shaping
  • affecting the rate of fibrils formation
  • involved in the differentiation of retinal glanglion cells and in suppression of tumorigenic potential of mammary tumor cells
  • playing a role in matrix assembly
  • suppressing the growth of various tumor cell lines
  • having a key role in the regulation of stromal fibril assembly, primarily regulating lateral fibril growth
  • with BGN have a coordinate and cooperative relationship in the regulation of stromal fibrillogenesis
  • can directly boost the ability of neurons to extend axons within chondroitin sulfate proteoglycans or myelin rich environments
  • plays complex roles in both normal vascular physiology and the pathogenesis of various types of vascular disorders
  • plays an important role in the highly orchestrated process of dentin mineralization
  • important role of decorin in the extracellular matrix
  • able to inhibit CTGF action inhibiting CTGF-mediated fibronectin accumulation and expression and stress fiber formation
  • small leucine-rich proteoglycan involved in regulating matrix organization and cell signaling
  • BGN and DCN may have sequential roles in the tendon response to injury
  • BGN and DCN are class I members of the small leucine-rich proteoglycan (SLRP) family that regulate collagen fibril size
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text histogenesis and organogenesis
    PATHWAY
    metabolism
    signaling
  • ITGB1-WNT7A-DCN pathway promotes proliferation and differentiation of neuroepithelial cells, and identify DCN as a novel neurogenic factor in the central nervous system
    • a component
  • small collagen-binding proteoglycan constituent of the extracellular matrix
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • pepsin-derived fragments containing the collagenous domain of C1q
  • thrombospondin
  • collagen type VI
  • heparin cofactor II
  • collagen XIV
  • TGF-beta
  • epidermal growth factor (EGF) receptor
  • group IIA phospholipase A(2)
  • microfibrillar proteins MAGP-1 and fibrillin-1
  • Wnt-1-induced secreted protein 1, WISP-1
  • biglycan
  • alpha2HS-glycoprotein, alpha2HSG
  • filamin-A
  • tumour necrosis factor-alpha, TNF-alpha
  • pulmonary surfactant protein D
  • BGN during corneal development and DCN may have a primary role in regulating fibril assembly, a function that can be fine-tuned by biglycan during early development
  • connective tissue growth factor (CTGF CCN2)
  • interacts with CTGF and regulates its biological activity, and is able to inhibit CTGF action through its LRR12
  • OTUB1 interacted with DCN (the overexpression of OTUB1 enhanced the ubiquitination and degradation of DCN in mesangial cells (MC)
  • has an impact on the biology of ITGA2B1 integrin and the vimentin intermediate filament system
    • cell & other
    REGULATION
    activated by BMP1-1 or BMP1-3 isoforms
    induced by CTGF, that induces the synthesis of its negative regulator decorin
    Other proteolytic degradation of DCN by MMP-2, MMP-3 and MMP-7
    ASSOCIATED DISORDERS
    corresponding disease(s) CSCD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in a high percentage of the follicular thyroid adenomas, follicular thyroid carcinomas, and follicular variant of papillary thyroid carcinomas
    tumoral     --low  
    in prostate cancer stroma compared to non-malignant prostate stroma
    Susceptibility
    Variant & Polymorphism
    Candidate gene certainly providing a usable biomarker for distinguishing between benign and malignant vascular tumors in patients
    Marker
    Therapy target useful as potential targets for thyroid tumor treatment
    ANIMAL & CELL MODELS
  • (Dcn(-/-) mice display a phenotype similar to that of Ehlers-Dabnlos patients