| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
| deletion
|
|
| |
in familial and sporadic paraganglioma | | tumoral
|
|
|
| loss of function
| |
in paraganglioma and pheochromocytoma | | tumoral
| germinal mutation
|
|
|
| |
increases oxidative stress, resulting in apoptosis and tumorigenesis | | tumoral
|
|
|
| loss of function
|
epigenetic inactivation of the SDHC gene locus with functional impairment of the SDH complex is a plausible alternate mechanism of tumorigenesis in Carney triad (CT)  | |
