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FLASH GENE
Symbol SDHC contributors: mct/ - updated : 07-05-2019
HGNC name succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
HGNC id 10682
Corresponding disease
PGL3 hereditary paraganglioma 3
Location 1q23.3      Physical location : 161.284.165 - 161.334.533
Synonym name
  • succinate-ubiquinone oxide reductase cytochrome B large subunit, complex 2 of the respiratory chain
  • succinate dehydrogenase, cyb L subunit
  • cytochrome B large subunit of complex II
  • Synonym symbol(s) CYBL, QPS1, PGL3, CYB560, QPS1, SDH3
    EC.number 1.3.99.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE gene in gene
    text embedded in intron 10 of sulfonylurea receptor gene SUR1
    STRUCTURE 50.38 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    ITLN2 1q22-q23.5 intelectin 2 F11R 1q21.2-q21.3 F11 receptor USF1 1q22-q23 upstream transcription factor 1 LOC388708 1 similar to KAT protein LOC257106 1q23.1 hypothetical protein LOC257106 LNIR MGC33338 1q23.1 hypothetical protein MGC33338 PFDN2 1q23.1 prefoldin 2 NIT1 1q21-q22 nitrilase 1 DEDD 1q21.3 death effector domain containing HSPC155 1q23.1 hypothetical protein HSPC155 USP21 1q22 ubiquitin specific protease 21 PPOX 1q22 protoporphyrinogen oxidase B4GALT3 1q21-q23 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 ADAMTS4 1q23 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4 NDUFS2 1q23 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) FCER1G 1q23 Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide APOA2 1q21-q23 apolipoprotein A-II FLJ12770 1q23.1 hypothetical protein FLJ12770 NR1I3 1q23.1 nuclear receptor subfamily 1, group I, member 3 MPZ 1q22 myelin protein zero (Charcot-Marie-Tooth neuropathy 1B) SDHC 1q21 succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa LOC257177 1q23.1 similar to hypothetical protein MGC20470 LOC148430 1q23.1 similar to ribosomal protein S2; 40S ribosomal protein S2 LOC388709 1 LOC388709 LOC388710 1 LOC388710 FCGR2A 1q23 Fc fragment of IgG, low affinity IIa, receptor for (CD32) HSPA6 1q heat shock 70kDa protein 6 (HSP70B') FCGR3A 1q23 Fc fragment of IgG, low affinity IIIa, receptor for (CD16) FCGR3B 1q23 Fc fragment of IgG, low affinity IIIb, receptor for (CD16) FCGR2B 1q23 Fc fragment of IgG, low affinity IIb, receptor for (CD32) FREB 1q23.1 Fc fragment of IgG, low affinity IIb, receptor for (CD32) FLJ31052 1q23.1 hypothetical protein FLJ31052
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2694 - 150 - 2018 29126304
    6 - 2858 - 169 - 2018 29126304
    4 - 2699 - 116 - 2018 29126304
    5 - 2756 - 135 - 2018 29126304
    4 - 2592 - 116 - 2018 29126304
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     liver    
    Endocrineparathyroid   highly
    Reproductivefemale systemuteruscervix highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • hydrophobic integral membrane-anchor peptide
  • secondary structure four nuclear encoded subunit (A,B,C,D)
    HOMOLOGY
    interspecies homolog to C.elegans t07c4.7
    Homologene
    FAMILY
  • cytochrome b560 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • succinate-ubiquinone oxidoreductase, catalyzing the seventh step of the citric acid cycle (tricarboxylic acid cycle)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism organic acid
    signaling
    a component
  • component 3 of complex II of mitochondrial respiratory chain (CII-3), oxidative phosphorylation,(OXPHOS)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PGL3
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in familial and sporadic paraganglioma
    tumoral       loss of function
    in paraganglioma and pheochromocytoma
    tumoral germinal mutation      
    increases oxidative stress, resulting in apoptosis and tumorigenesis
    tumoral       loss of function
    epigenetic inactivation of the SDHC gene locus with functional impairment of the SDH complex is a plausible alternate mechanism of tumorigenesis in Carney triad (CT)
    Susceptibility to head and neck paraganglioma
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS