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FLASH GENE
Symbol SDHD contributors: mct/npt - updated : 16-03-2009
HGNC name succinate dehydrogenase complex, subunit D, integral membrane protein
HGNC id 10683
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1382 10.9 159 - Hirawake (1997)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
 salivary gland   highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Connectivebone   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • membrane-anchor peptide
    • secondary structure four subunits, iron sulfur protein 2 membrane anchoring protein
    conjugated FlavoP , MetalloP , Other
    mono polymer tetramer
    HOMOLOGY
    interspecies homolog to C.elegans c02b4.3
    Homologene
    FAMILY
  • CybS family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • succinate-ubiquinone oxidoreductase, catalyzing the seventh step of the citric acid cycle (tricarboxylic acid cycle)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism organic acid
    signaling
    tricarboxylic acid
    a component
  • component 4 of complex II of mitochondrial respiratory chain (CII-4), oxidative phosphorylation,(OXPHOS)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PGL1 , CWS3
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in pheochromocytoma
    tumoral   deletion    
    in Merkel cell carcinoma
    tumoral somatic mutation      
    in midgut carcinoid
    tumoral germinal mutation      
    in familial head and neck paraganglioma
    tumoral       loss of function
    in pheochromocytoma and paraganglioma
    tumoral germinal mutation      
    in Cowden and Cowden-like syndromes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS