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FLASH GENE

Symbol

HYAL1

contributors: mct/npt - updated : 10-06-2009

HGNC name	hyaluronoglucosaminidase 1
HGNC id	5320

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MPS9

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in bladder and prostate cancer cells (Lokeshwar 2008) tumoral       loss of function inactivated in head and neck squamous cell carcinomas by aberrant splicing premRNA tumoral     --over   in advanced stages of bladder cancer (Chao 2007)

Susceptibility

Variant & Polymorphism

Candidate gene	marker for cancer diagnosis and a molecular determinant of tumor growth, invasion, and angiogenesis (Lokeswahr 2008)
Marker
Therapy target	anti-hyaluronidase and high-hyaluronidase treatments for cancer

ANIMAL & CELL MODELS