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FLASH GENE
Symbol MEIS2 contributors: mct/npt - updated : 05-02-2019
HGNC name Meis homeobox 2
HGNC id 7001
ASSOCIATED DISORDERS
corresponding disease(s) DEL15Q14
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
extensively expressed in ovarian carcinomas and may play a role in ovarian carcinogenesis (Crijns 2007)
constitutional     --over  
is a molecular mechanism for high expression of mitotic genes that is frequently observed in cancers of poor prognosis
Susceptibility
Variant & Polymorphism
Candidate gene
  • for cleft palate and heart defect
  • combinatorial expression of Meis family proteins might be a candidate mechanism for the differential regulation of eye growth among vertebrate species (Heine 2008)
  • suitable marker for the study of amacrine cell diversity and development in addition to providing evidence for the stepwise specification of the glycinergic and GABAergic neurotransmitter phenotypes during amacrine cell differentiation (Bumsted-O'Brien 2007)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS