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FLASH GENE
Symbol MEIS2 contributors: mct/npt - updated : 05-02-2019
HGNC name Meis homeobox 2
HGNC id 7001
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix-turn-helix, DNA binding domain, TALE (three AA loop extension between helices) subfamily
    • HOMOLOGY
    interspecies ortholog to murine Meis1 (myeloid ecotropic viral integration site 1)
    intraspecies homolog to PBX1
    Homologene
    FAMILY
  • TALE/MEIS homeobox family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • acting as a transcription repressor
  • critical downstream effector within an essential homeoprotein network that serving a rate-limiting regulatory role in MLL leukemogenesis (Wong 2007)
  • midbrain specific marker upregulated concomitantly with the morphological transformation of hindbrain to midbrain (Vennemann 2008)
  • maintain retinal progenitor cells in a rapidly proliferating state and control the expression of some ocular-determination genes and components of the cell cycle machinery (Heine 2008)
  • in combination with PBX3 and FOXP2, may play a pivotal role in the development of striosomal neurons of the striatum and the islands of Calleja (Takahashi 2008)
  • TALE-homeodomain protein necessary and sufficient for tectal development (Agoston 2009)
  • competes with the Groucho co-repressor TLE4 for binding to OTX2 and specifies tectal fate without induction of a secondary midbrain-hindbrain boundary organizer (Agoston 2009)
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS cardiovascular , development
    text transcription co-repressor
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding cooperatively with the heterodimer E2A/myogenic transcription factors
    RNA
    small molecule
    protein
  • co-operation between TLX1 and MEIS1, MEIS2 proteins may have a significant role in T-cell leukemogenesis
  • interdependent regulatory loops involving PAX3 and PAX7 in the dorsal mesencephalic vesicle modulate MEIS2 expression
  • is a direct target gene of MEIS2 and is required for MEIS2 to upregulate mitotic genes
  • crucial role for RING1-dependent repression of MEIS2 and likely also MEIS1 for distal specification
  • PBX1 regulates adult neural cell fate determination in a manner beyond that of its heterodimerization partner MEIS2
  • MEIS2 is a novel player in MN1-induced leukemogenesis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL15Q14
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    extensively expressed in ovarian carcinomas and may play a role in ovarian carcinogenesis (Crijns 2007)
    constitutional     --over  
    is a molecular mechanism for high expression of mitotic genes that is frequently observed in cancers of poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • for cleft palate and heart defect
  • combinatorial expression of Meis family proteins might be a candidate mechanism for the differential regulation of eye growth among vertebrate species (Heine 2008)
  • suitable marker for the study of amacrine cell diversity and development in addition to providing evidence for the stepwise specification of the glycinergic and GABAergic neurotransmitter phenotypes during amacrine cell differentiation (Bumsted-O'Brien 2007)
    • Marker
    Therapy target
    ANIMAL & CELL MODELS