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FLASH GENE

Symbol

MEIS2

contributors: mct/npt - updated : 05-02-2019

HGNC name	Meis homeobox 2
HGNC id	7001

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_170677 13 splicing 3721 NP_733777 43.8 401 - Yang (2000) also called variant a NM_170674 13 splicing 3700 NP_733774 43.1 394 - Yang (2000) also called variant b NM_170675 12 splicing 3625 NP_733775 51.8 477 - Yang (2000) also called variant c NM_170676 12 splicing 3604 NP_733776 51.1 470 - Yang (2000) also called variant d variant e - splicing 3623 isoform e 32.8 302 - Yang (2000) NM_002399 13 splicing 3110 NP_002390 41.5 381 - Yang (2000) also called variant f NM_172315 12 splicing 2775 NP_758526 42.3 388 - Yang (2000) also called variant g NM_172316 13 splicing 3175 NP_758527 33.6 306 - Yang (2000) also called variant h

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen           thymus         Lymphoid/Immune lymph node         nervous brain basal nuclei putamen     Visual eye retina     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Visual amacrine cell

cell lineage	hematopoietic cell lineage
cell lines
fluid/secretion

at STAGE

physiological period

fetal

Text	preferentially expressed in distinct cell populations in the developing striatum (Kaoru 2010)

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

helix-turn-helix, DNA binding domain, TALE (three AA loop extension between helices) subfamily

HOMOLOGY

interspecies

ortholog to murine Meis1 (myeloid ecotropic viral integration site 1)

intraspecies

homolog to PBX1

Homologene

FAMILY

TALE/MEIS homeobox family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	acting as a transcription repressor
	critical downstream effector within an essential homeoprotein network that serving a rate-limiting regulatory role in MLL leukemogenesis (Wong 2007)
	midbrain specific marker upregulated concomitantly with the morphological transformation of hindbrain to midbrain (Vennemann 2008)
	maintain retinal progenitor cells in a rapidly proliferating state and control the expression of some ocular-determination genes and components of the cell cycle machinery (Heine 2008)
	in combination with PBX3 and FOXP2, may play a pivotal role in the development of striosomal neurons of the striatum and the islands of Calleja (Takahashi 2008)
	TALE-homeodomain protein necessary and sufficient for tectal development (Agoston 2009)
	competes with the Groucho co-repressor TLE4 for binding to OTX2 and specifies tectal fate without induction of a secondary midbrain-hindbrain boundary organizer (Agoston 2009)

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

cardiovascular , development

text	transcription co-repressor

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binding cooperatively with the heterodimer E2A/myogenic transcription factors

RNA

small molecule

protein	co-operation between TLX1 and MEIS1, MEIS2 proteins may have a significant role in T-cell leukemogenesis
	interdependent regulatory loops involving PAX3 and PAX7 in the dorsal mesencephalic vesicle modulate MEIS2 expression
	is a direct target gene of MEIS2 and is required for MEIS2 to upregulate mitotic genes
	crucial role for RING1-dependent repression of MEIS2 and likely also MEIS1 for distal specification
	PBX1 regulates adult neural cell fate determination in a manner beyond that of its heterodimerization partner MEIS2
	MEIS2 is a novel player in MN1-induced leukemogenesis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DEL15Q14

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   extensively expressed in ovarian carcinomas and may play a role in ovarian carcinogenesis (Crijns 2007) constitutional     --over   is a molecular mechanism for high expression of mitotic genes that is frequently observed in cancers of poor prognosis

Susceptibility

Variant & Polymorphism

Candidate gene	for cleft palate and heart defect
	combinatorial expression of Meis family proteins might be a candidate mechanism for the differential regulation of eye growth among vertebrate species (Heine 2008)
	suitable marker for the study of amacrine cell diversity and development in addition to providing evidence for the stepwise specification of the glycinergic and GABAergic neurotransmitter phenotypes during amacrine cell differentiation (Bumsted-O'Brien 2007)
Marker
Therapy target

ANIMAL & CELL MODELS