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FLASH GENE
Symbol SLC25A20 contributors: mct/npt - updated : 05-07-2006
HGNC name solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
HGNC id 1421
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three tandemly repeated mitochondrial carrier protein domains
  • six transmembrane spanning segments
  • a distinct motif, RXXPANAAXF, within its six transmembrane alpha-helix (De Lucas 2008)
  • three solcar repeats
    • HOMOLOGY
    Homologene
    FAMILY
  • mitochondrial carrier family
    • CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • carnitine/acylcarnitine translocase, (carrier) nuclear encoded protein
  • mediating the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway
  • key molecule that transfers acylcarnitine esters in . exchange for free carnitine across the mitochondrial membrane in the mitochondrial beta-oxidation (Tachibana 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    text energy transfer
    PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CACT
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS