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FLASH GENE
Symbol RNF5 contributors: mct - updated : 03-11-2015
HGNC name ring finger protein 5
HGNC id 10068
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a ring (C3HC4-type) zinc finger motif
    • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to C.elegans (putative zinc finger gene)
    Homologene
    FAMILY RING finger protein family
    CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus,chromatin/chromosome
    text
  • anchored to the outer membrane of the ER
  • both TMEM173 and RNF5 were located at the mitochondria and endoplasmic reticulum (ER) and viral infection caused their redistribution to the ER and mitochondria, respectively
    • basic FUNCTION
  • E3 ubiquitin ligase implicated in motility and endoplasmic reticulum stress response
  • ER-anchored RING finger E3 ligase implicated in muscle organization and in recognition and processing of malfolded proteins
  • importance of RNF5 in muscle physiology and its deregulation in ER stress associated muscular disorders
  • regulator of breast cancer progression through its effect on actin cytoskeletal alterations, which also affect sensitivity of breast cancer cells to cytoskeletal targeting antineoplastic agents
  • is a ubiquitin ligase anchored to the ER membrane implicated in ERAD via ubiquitination of misfolded proteins
  • negatively regulates virus-triggered signaling by targeting TMEM173 for ubiquitination and degradation at the mitochondria
  • RNF5-mediated ubiquitination and degradation of MAVS is one of the mechanisms of the regulation of virus-triggered induction of type I IFNs and cellular antiviral response
  • is involved in Pendrin (SLC26A4) degradation
  • RNF5-mediated control of membranal ATG4B reveals a novel layer in the regulation of ATG8 processing and autophagy
  • RNF5 regulates the turnover of specific G protein-coupled receptors by ubiquitinating JKAMP and preventing proteasome recruitment
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • RNF5 effect on JKAMP is seen prior to and after ER stress response, thereby highlighting a novel mechanism to limit ERAD and proteasome assembly at the ER, to the actual ER stress response
  • RNF5 negatively regulates virus-triggered signaling by targeting TMEM173 for ubiquitination and degradation at the mitochondria
  • interacted with MAVS at mitochondria in a viral infection-dependent manner
  • regulates basal levels of autophagy by controlling the stability of a select pool of the cysteine protease ATG4B
  • interaction between RNF5 and the ADRB2 as well as the prostaglandin D2 receptor (DP)
  • RNF5 ubiquitinated JNK-associated membrane protein (JKAMP), a protein that recruits the proteasome to the ER membrane and that is negatively regulated by RNF5-mediated ubiquitination
  • RNF185 and RNF5 are a novel E3 ligase module central to the control of CFTR degradation
  • SYVN1 and RNF5 may be negative regulators of disease-associated transporter ABCG5/ABCG8
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer with decreased survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    respiratoryCF (mucoviscidosis) 
    RNF5 is a target for therapeutic modalities to antagonize mutant CFTR proteins
    ANIMAL & CELL MODELS