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FLASH GENE

Symbol

RNF5

contributors: mct - updated : 03-11-2015

HGNC name	ring finger protein 5
HGNC id	10068

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006913 6 - 1176 NP_008844 - 180 - 1997 9533025

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a ring (C3HC4-type) zinc finger motif

conjugated

MetalloP

HOMOLOGY

interspecies

homolog to C.elegans (putative zinc finger gene)

Homologene

FAMILY

RING finger protein family

CATEGORY

regulatory , DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,nucleus,chromatin/chromosome
text	anchored to the outer membrane of the ER
	both TMEM173 and RNF5 were located at the mitochondria and endoplasmic reticulum (ER) and viral infection caused their redistribution to the ER and mitochondria, respectively

basic FUNCTION	E3 ubiquitin ligase implicated in motility and endoplasmic reticulum stress response
	ER-anchored RING finger E3 ligase implicated in muscle organization and in recognition and processing of malfolded proteins
	importance of RNF5 in muscle physiology and its deregulation in ER stress associated muscular disorders
	regulator of breast cancer progression through its effect on actin cytoskeletal alterations, which also affect sensitivity of breast cancer cells to cytoskeletal targeting antineoplastic agents
	is a ubiquitin ligase anchored to the ER membrane implicated in ERAD via ubiquitination of misfolded proteins
	negatively regulates virus-triggered signaling by targeting TMEM173 for ubiquitination and degradation at the mitochondria
	RNF5-mediated ubiquitination and degradation of MAVS is one of the mechanisms of the regulation of virus-triggered induction of type I IFNs and cellular antiviral response
	is involved in Pendrin (SLC26A4) degradation
	RNF5-mediated control of membranal ATG4B reveals a novel layer in the regulation of ATG8 processing and autophagy
	RNF5 regulates the turnover of specific G protein-coupled receptors by ubiquitinating JKAMP and preventing proteasome recruitment

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	zinc Zn2+

protein	RNF5 effect on JKAMP is seen prior to and after ER stress response, thereby highlighting a novel mechanism to limit ERAD and proteasome assembly at the ER, to the actual ER stress response
	RNF5 negatively regulates virus-triggered signaling by targeting TMEM173 for ubiquitination and degradation at the mitochondria
	interacted with MAVS at mitochondria in a viral infection-dependent manner
	regulates basal levels of autophagy by controlling the stability of a select pool of the cysteine protease ATG4B
	interaction between RNF5 and the ADRB2 as well as the prostaglandin D2 receptor (DP)
	RNF5 ubiquitinated JNK-associated membrane protein (JKAMP), a protein that recruits the proteasome to the ER membrane and that is negatively regulated by RNF5-mediated ubiquitination
	RNF185 and RNF5 are a novel E3 ligase module central to the control of CFTR degradation
	SYVN1 and RNF5 may be negative regulators of disease-associated transporter ABCG5/ABCG8

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast cancer with decreased survival

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed respiratory CF (mucoviscidosis)   RNF5 is a target for therapeutic modalities to antagonize mutant CFTR proteins

ANIMAL & CELL MODELS