| basic FUNCTION
| transcriptional repressor in a histone acetylase dependent or independent manner |
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playing a role during cellular proliferation, adenovirus replication and oncogenic transformation |
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negative control of cell proliferation |
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involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex |
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dehydrogenase activity |
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attenuates KLF4-mediated transcriptional activation through the physical interaction with KLF4  |
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can interact with a polycomb group protein complex which participates in regulation of gene expression during development |
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acts in the nucleus as transcriptional corepressor and in the cytoplasm as regulators of Golgi apparatus fission |
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promotes cell survival through the maintenance of mitotic fidelity |
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corepressor that regulates transcription of the CYP17 gene by periodically interacting with steroidogenic factor-1 in response to ACTH signaling |
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transcriptional corepressor with tumorigenic potential that targets the promoter of the tumor suppressor gene E-cadherin |
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can recruit PNN to CTBP-associated complexes, resulting in Pnn-dependent chromatin remodeling at the E-cadherin promoter |
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is required for macropinocytic internalization and infection of ectovirus 1 |
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target of PAK1 and is bifunctionally involved in membrane traffic and transcriptional repression of cell cycle, cancer, and innate immunity pathways |
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role for LCOR and CTBP1 as attenuators of progesterone-regulated transcription, suggesting that LCOR and CTBP1 can act to enhance transcription of some genes |
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central role to control the actions of many transcriptional factors, in large part, by recruitment and activation of a range of chromatin remodeling enzymes |
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transcriptional co-repressor and metabolic sensory protein, which often represses tumor suppressor genes |
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required for the ability of BCL3 to repress gene transcription, CTBP1 is also required for the oncogenic potential of BCL3 and for its ability to inhibit UV-mediated cell apoptosis in keratinocytes) |
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with TBL1XR1, are key regulators of different properties of the BCL3 oncoprotein |
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ZFPM1, ZFPM2, and CTBP1 and CTBP2 are partners of GATA2, GATA3 proteins in the control of adipocyte proliferation and differentiation |
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key transcriptional coregulator in adipose tissue |
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transcriptional repressor which plays a significant role in the regulation of cell proliferation and tumor progression |
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AMPK and CTBP1 act as energy sensors and cause cell death upon glucose deprivation |
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CTBP1, CTBP2 are essential pro-survival proteins in neurons and their downregulation contributes significantly to neuronal apoptosis via the de-repression of pro-apoptotic genes |
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potential functions and transcriptional activities of CTBP1 in the context of epithelial-mesenchymal interplay, suggesting that CTBP1 has a pathogenic role in hair follicle morphogenesis and differentiation |
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CTBP1 and CTBP2 are closely related and act as transcriptional corepressors when activated by nicotinamide adenine dinucleotide binding to their dehydrogenase domains |
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role of CTBP1, a transcriptional co-repressor enriched in presynapses and nuclei, in the activity-driven reconfiguration of gene expression in neurons |
