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FLASH GENE

Symbol

GPR35

contributors: mct/npt/shn/pgu - updated : 24-03-2011

HGNC name	G protein-coupled receptor 35
HGNC id	4492

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	DEL2Q37 chromosome 2q subtelomeric deletion syndrome
Location	2q37.3      Physical location : 241.544.824 - 241.570.675
Synonym name	G-protein coupled receptor 35
	KYNA receptor
	kynurenic acid receptor

DNA

TYPE	functioning gene
STRUCTURE	6.02 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D2S125 - D2S395 - GPR35 - D2S140 - D2S2585 - qter

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005301 (transcript variant 1) 2 splicing 1875 NP_005292 - 309 predominantly detected in immune cells and the gastrointestinal tract 2006 16754668 NM_001195382.1 (transcript variant 3) 2 splicing 2179 NP_001182311 - 340 - 2006 16754668 NM_001195381.1 (transcript variant 2) 2 splicing 2293 NP_001182310 - 340 - 2006 16754668

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive intestine large intestine colon       intestine small intestine         salivary gland       highly   stomach         Endocrine pancreas         Lymphoid/Immune spleen       highly   thymus       highly Reproductive female system ovary       Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid         Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Endocrine islet cell (alpha,beta...)

cell lineage	invariant natural killer T (iNKT) cells
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

HOMOLOGY

interspecies	ortholog to GPR35, GPR35
	ortholog to GPR35, Pan troglodytes
	ortholog to Gpr35, Mus musulus
	ortholog to Gpr35, Rattus norvegicus

Homologene

FAMILY

G protein-coupled receptor family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm

basic FUNCTION	receptor having rhodopsin-like receptor activity
	functions as a receptor for the kynurenine pathway intermediate kynurenic acid
	having a potential role in regulating neuronal excitability and synaptic release
	receptor for lysophosphatidic acid
	play an important role in immune modulation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DEL2Q37

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   expressed in gastric cancer

Susceptibility

Variant & Polymorphism

Candidate gene	for brachymetaphalangism and/or obesity in the del2q37 syndrome
Marker
Therapy target
	System Type Disorder Pubmed diabete metabolic syndrom   potential exploratory target for the treatment of both metabolic disorders and hypertension

ANIMAL & CELL MODELS