| protein
| binding CD14 required for LPS recognition |
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binding directly to TLR2 |
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binding MYD88 and TIRAP via their TIR domain |
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toll interacting protein, TOLLIP ( |
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Gp96 ( |
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myeloid differentiation protein-2, MD-2 ( |
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beta-defensin 2, mDF2beta ( |
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Bruton's tyrosine kinase, Btk ( |
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toll-like receptor 5, TLR5 ( |
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JNK-interacting protein 3, JIP3 ( |
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TICAM-1 and TICAM-2 ( |
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spleen tyrosine kinase, SYK ( |
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NAD(P)H oxidase 4 isozyme ( |
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receptor-interacting protein 2, RIP2 ( |
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High mobility group box 1, HMGB1 ( |
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PRotein Associated with Tlr4, PRAT4B ( |
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Myeloid Differentiation primary response protein 88, MyD88 ( |
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RAB7B is a negative regulator of TLR4 signaling, potentially by promoting the translocation of TLR4 into lysosomes for degradation |
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S1PR1 or S1PR3 |
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lipopolysaccharide, LPS ( |
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TLR4 requires myeloid differentiation (LY96), and both TLR2 and TLR4 signal need myeloid differentiation factor (MYD88) |
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FOXO1 |
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PRDX1 |
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KCNJ3 |
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is one of the most important functional receptors mediating biological activities of HSPA14 |
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LY96 binds LPS with high affinity and is critical for TLR4-dependent signal transduction |
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insufficient LPS-induced chaperone expression links TLR4 signaling to endoplasmic reticulum stress |
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LPS induced the increased physical association of TLR4 with HSP90B1 but not with HSPA5 |
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CNPY4 positively regulates TLR4 surface expression but plays a negatively regulatory role in the surface expression of TLR1 |
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TLR4 is expressed on the LGR5-positive intestinal stem cells |
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BBC3 mediates the increased apoptosis and reduced proliferation within intestinal crypts that is induced by TLR4 |
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LRRFIP2 is involved in NFKB1 activation following stimulation of TLR4 |
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IL10 activates TLR4 and requires MYD88 for cardiomyocyte survival |
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not only TLR4 signaling, but also CD180 appears to be an essential accessory for immune responses through TLR2 signaling |
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by inhibiting the degradation of TRAF3 during TLR4 activation, USP25 enables a balanced innate immune response |
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LY96 is essential for lipopolysaccharide (LPS) recognition of Toll-like receptor 4 (TLR4) but not for cell surface expression |
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SIK1 and SIK3 negatively regulate TLR4-mediated signaling through the interruption of TAB2-TRAF6 complex and thereby the inhibition of ubiquitination of TRAF6 |
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PRSS8 releases the ectodomain of TLR4 by cleaving it, which results in a reduction in the full-length form and reduces the activation of TLR4 |
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TNFAIP8L2 can regulate TLR4 inflammatory effect and inhibit further amplification of cascade reaction via CASP8 |
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CD14 is an endogenous ligand for CD33 and ligation of CD33 with CD14 modulates with the presentation of LPS from CD14 to TLR4, leading to down-regulation of TLR4-mediated signaling |
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TLR4-mediated expression of ITGAM in monocytes plays a pivotal role on monocyte adhesion to vascular endothelium, leading to increased foam cell formation in the development of atherosclerosis |
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HMGN1 is a potent alarmin that binds TLR4 and induces antigen-specific Th1 immune responses |
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SLC16A4 is required for macrophage activation upon TLR2 and TLR4 stimulations |
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TLR4 adaptor, myeloid differentiation factor 2 (LY96), binds specifically to the cytokine-inducing disulfide isoform of HMGB1, to the exclusion of other isoforms |
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THBD promotes diabetic wound healing by regulating TLR4 expression |
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WDFY1 is a crucial adaptor protein in the TLR3/4 signaling pathway |
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WDFY1 recruits the signaling adaptor TICAM1 to TLR3 and TLR4, thereby potentiating signaling from these pattern recognition receptors (PRRs) |
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ANPEP negatively regulates TLR4 signaling, thereby balancing the innate response by maintaining the inflammatory equilibrium critical to innate immune regulation |
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TLR4 recruits TICAM2 as a sorting adaptor to facilitate the interaction between TLR4 and TICAM1 and then initiate TICAM1-dependent IRF3 activation |
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HAVCR2-signaling inhibited phosphorylation of IRF3, a TLR4 downstream transcriptional factor regulating macrophage polarization |
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MAP2K1 is required for TLR4 mediated ERK activation and in turn regulates the production of IL10 and IL12A |
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TRIM38 negatively regulates TLR3/4-mediated innate immune and inflammatory responses by two sequential and distinct mechanisms |
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TICAM2 bridges TLR4 and TICAM1 for LPS signaling in the endosome |
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HSPD1 is involved in the stimulation of VSMC migration, via TLR4 and ERK MAPK activation |
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important distinction between the TICAM1-mediated signaling pathways of TLR4 and TLR3 |
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ANXA2 directly exerted negative regulation of inflammatory responses through TLR4-initiated TICAM2-TICAM1 pathway occurring on endosomes |
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PRG4 binds to TLR2 and TLR4 and this binding mediates a novel anti-inflammatory role for PRG4 |
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SYK negatively regulates TLR4-mediated production of IFNB1 and IL10 and promotes inflammatory responses in dendritic cells through divergent regulation of downstream PI3K-AKT1 and NFKB1 signaling pathways |
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CD14 is a co-receptor of TLR4 in the S100A9-induced cytokine response |
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critical role of SPI1 in the regulation of TLR1, 2, 4 and of CD14 |
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CSF3 downregulates TLR1, TLR2 and TLR4 in a time- and dose-dependent fashion in human monocytes |
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critical role of TOLLIP in the early phase of TLR4-mediated neuroinflammation |
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E3 ubiquitin ligase ZNRF1 modulates CAV1 protein stability to regulate Toll-like receptor (TLR) 4-triggered immune responses |
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CAMP selectively modulated synthesis of TLR4 and TLR9 in intestinal epithelium, but only when cells were exposed to virulence factors, mostly from apical surfaces |
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CD180 is implicated in the pathological process of multiple cardiovascular diseases through its functional and physical interactions with Toll& |
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8209;like receptor 4 (TLR4) |
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CD180 ameliorates hypoxia& |
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824;reoxygenation injury in cardiac microvascular endothelial cells by suppressing TLR4& |
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824;MAPKs& |
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824;NFKB1 signaling |
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interaction of FGL2 and TLR4 may in part contribute to the activation of inflammatory signaling pathways in macrophages |
