protein
| activating MITF in synergy with PAX3 |
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regulating EDNRB in the enteric nervous system |
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interactions between SOX10, EDN3 and EDNRB during enteric nervous system and melanocyte development |
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binds to regulatory sequences in target genes via its conserved high mobility group domain |
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interaction with ARMCX3 (SOX10 is a membrane-associated factor whose transcriptional function is increased by direct interactions with ARMCX3) |
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associates with OLIG1, and the OLIG1/SOX10 complex activates MBP(myelin basic protein) transcription via conserved DNA sequence motifs in the MBP promoter region |
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colocalization of EGR2 binding with SOX10, a transcription factor required for Schwann cell specification and other stages of Schwann cell development |
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MEF2C is direct transcriptional target of SOX10 and MEF2A via a evolutionarily conserved enhancer |
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in neural crest cells TFAP2A directly activates expression of SOX10, which encodes a transcription factor essential for neural crest development |
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SOX10 activates DHH expression in Schwann cells via an enhancer that is located in intron 1 of the DHH gene |
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SOX10 regulation by PHOX2B is pivotal for the development and pathogenesis of the autonomic ganglia |
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functions during terminal differentiation of myelinating glia, at least in part by MED12-dependent recruitment of the Mediator complex |
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SOX10 and ITGB1 interaction in enteric neural crest cell migration |
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TWIST1 interacts with the pro-neural factor SOX10 via its Twist-box domain and binds to the PHOX2B promoter to repress transcriptional activity |
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MYRF cooperates with SOX10 to implement the myelination program as evident from the physical interaction between both proteins and the synergistic activation of several myelin-specific genes |
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during oligodendrocyte maturation, TCF7L2 recruits and cooperates with SOX10 to promote myelination |
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TEAD1 is a novel regulator of PMP22 expression during development in concert with SOX10 and EGR2 |