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FLASH GENE
Symbol MNAT1 contributors: mct - updated : 18-05-2011
HGNC name menage a trois 1 (CAK assembly factor)
HGNC id 7181
Location 14q23      Physical location : 61.201.458 - 61.435.396
Synonym name
  • cyclin H assembly factor
  • cyclin G1 interacting protein
  • CDK-activating kinase assembly factor MAT1
  • CDK7/cyclin-H assembly factor
  • Synonym symbol(s) MAT1, RNF66, CAP35, TFB3
    DNA
    TYPE functioning gene
    STRUCTURE 233.94 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1397 - 309 - 1995 8521818
    7 - 1271 - 267 - 1995 8521818
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal zinc finger
  • ubiquitin-interacting motif (UIM) repeat
  • a coiled-coil domain in the middle that interacts with the C-terminal half of DMAP1
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • CDK activating kinase (CAK1) assembly factor MAT1 (ménage à trois), involved in cell cycle control and in RNA transcription by rna polymerase 2
  • requirement in the operation of PPARGC1A coactivators that control cell metabolism
  • inhibits peroxisome proliferator-activated receptor gamma-mediated adipocyte differentiation
  • assembly factor that appears to be essential for the formation of an active CDK-cyclin complex
  • CELLULAR PROCESS cell cycle
    nucleotide, repair
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    text cell cycle control
    PATHWAY
    metabolism
    signaling
    a component
  • component of a ternary complex with CDK7 and CCNH (see symbols)
  • associating in the multisubunit complex TFIIH (GTF2H)
  • trimeric CDK7/cyclin H/MNAT1 complex functions in cell cycle regulation, as the Cdk-activating kinase, and in transcription, as a module of the general transcription factor TFIIH
  • member of the DDR1 kinase complex that is crucial for cell cycle progression and that regulates CDK phosphorylation as well as the general transcription factor TFIIH (
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • interaction of MAT1 with RB1 stimulates the phosphorylation of RB1 by the DDR1 complex and E2F-mediated trans-activation of genes that trigger the G1/S transition
  • interaction with DMAP1 (intrinsic negative cell cycle regulator that modulates the CAK kinase activity via interaction with MNAT1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS