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FLASH GENE
Symbol HR contributors: mct/npt - updated : 08-02-2016
HGNC name hairless homolog (mouse)
HGNC id 5172
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • single zinc finger domain protein
  • a novel and conserved six-cysteine motif
  • a LXXLL motif found in TRIPs (thyroid hormone receptor interactive proteins)
  • a Jumonji C (JmjC) domain that is conserved among a family of proteins with histone demethylase (HDM) activity
    • HOMOLOGY
    interspecies homolog to murine hairless
    Homologene
    FAMILY
  • transcription factor jumonji family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies
    basic FUNCTION
  • putative transcription factor and transcriptional corepressor
  • involved in hair development but also in the process of ossification during development
  • may have a crucial role in the telogen-anagen transition during hair follicle cycling (Wen 2009)
  • HR and the vitamin D receptor (VDR) play a critical role in the maintenance of hair growth
  • first gene identified to be implicated in hair-cycle regulation
  • transcriptional cofactor hairless (HR) that is required for white adipogenesis
  • putrescine-HR negative regulatory loop may have a large impact on epidermal homeostasis and hair follicle cycling
  • can demethylate monomethylated or dimethylated histone H3 lysine 9 (H3K9me1 or me2)
  • is a H3K9 demethylase that regulates epidermal homeostasis via direct control of its target genes
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HDAC
  • HR interacts with VDR and induces VDR relocalization in the nuclei
  • HR down-regulated DLX3 mRNA expression through suppression of DLX3 promoter activity
  • repressed the expression of Wnt inhibitors, including SOSTDC1, DKKL1, SFRP1, and SFRP2
  • exerts its proadipogenic effects by regulating the expression of PPARG, one of the central adipogenic transcription factors
  • expression of MSX2 was down-regulated by HR, which in turn down-regulated expression of FOXN1 and LEF1, MSX2 target genes
  • VDR-mediated control of DKKL1, SOSTDC1, and HR gene expression in keratinocytes
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ALUNC , APL , HMU1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target regulatory role of the U2HR offer a potential target for the development of therapeutic drugs to treat some forms of human hair loss or promote hair removal (Wen 2009)
    ANIMAL & CELL MODELS