Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | HR | contributors: mct/npt - updated : 08-02-2016 |
HGNC name | hairless homolog (mouse) |
HGNC id | 5172 |
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DNA |
TYPE | functioning gene |
STRUCTURE | 16.63 kb 19 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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regulatory sequence | Promoter |
text structure | an inhibitory upstream ORF in the 5' UTR (U2HR) (Wen 2009) |
MAPPING | cloned | Y | linked | N | status | confirmed |
Map | pter - D8S552 - D8S511 - D8S26 - D8S549 - (MSR1 - ATP6V1B2 ) - D8S254 - D8S261 - LPL LPL - D8S258 - D8S280 - D8S282 - [D8S560 - D8S298 - D8S1786 - D8S1733 - D8S1752 - D8S1739 ] - D8S1771 - D8S1809 - D8S278 - D8S283 - cen |
Authors | Ahmad (98), Nöthen (98), GeneMap (98), Sprecher (99) |
Text | [ALUNC , HR , APL ] |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | widely |
expressed in | (based on citations) | ||||||||||||||||||||
organ(s) |
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tissue |
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cells |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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HOMOLOGY |
interspecies | homolog to murine hairless |
Homologene |
FAMILY |
CATEGORY | transcription factor |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,nucleus,nucleoplasm,nuclear bodies |
basic FUNCTION | |
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CELLULAR PROCESS | nucleotide, transcription, regulation |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein | |
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cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) | ALUNC , APL , HMU1 |
Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
| regulatory role of the U2HR offer a potential target for the development of therapeutic drugs to treat some forms of human hair loss or promote hair removal (Wen 2009) |
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ANIMAL & CELL MODELS |