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FLASH GENE

Symbol

FOXM1

contributors: mct/pgu - updated : 16-09-2022

HGNC name	forkhead box M1
HGNC id	3818

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     from respiratory epithelium did not influence branching lung morphogenesis or epithelial proliferation, but impaired lung sacculation, delayed type I cell differentiation, and reduced expression of surfactant-associated proteins, causing respiratory failure after birth tumoral     --over   overexpressed in OCSCC tumoral     --over   overexpression of FOXM1, XIAP, and BIRC5 contributes to the development of drug-resistance and is associated with poor clinical outcome in breast cancer patients

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed respiratory lung   provide novel strategies for diagnosis, prevention, and treatment of respiratory distress syndrome in preterm infants cancer hemopathy   curcumin together with FOXM1 targeting agents may be effective for acute myeloid leukemia therapy cancer     targeting FOXM1 increases apoptosis and inhibits tumor growth cancer reproductive uterus FOXM1-PSMB4 axis could be a potential target for the treatment of cervical cancer

ANIMAL & CELL MODELS