basic FUNCTION
| important positive regulator of DNA replication and mitosis in a variety of cell types |
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proliferation-associated transcription factor, stimulating proliferation by promoting both G1/S- and G2/M-transition and implicated in tumorigenesis |
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embryonic transcriptional regulator, involved in cell proliferation |
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critical for surfactant homeostasis and lung maturation before birth and is required for adaptation to air breathing |
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has critical functions in tumor development and progression |
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regulate, variously, proliferation and/or spindle formation during the G2/M transition of the cell cycle |
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functions in SHH-induced neuroproliferation are restricted to the regulation of the G2/M transition in cerebellar granule neuron precursors, most probably through transcriptional effects on target genes such as those coding for B-type cyclins |
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a typical proliferation-associated transcription factor that stimulates proliferation by promoting S-phase entry as well as M-phase entry and is involved in proper execution of mitosis |
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regulates genes that control G1/S-transition, S-phase progression, G2/M-transition and M-phase progression |
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having two different transactivation mechanisms, the regulation of its transcriptional activity by proliferation versus anti-proliferation signals and its function in normal cell cycle progression and tumorigenesis |
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key regulator of oxidative stress that contributes to malignant transformation and tumor cell survival |
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transcriptionally active during a DNA-damage-induced G2 arrest and is essential for checkpoint recovery |
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critical involvement in maintenance of stem cell pluripotency |
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in cancer cells the interaction between FOXM1 and NPM1 is necessary for sustaining the level and localization of FOXM1 and it may be required for cancer progression |
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expression of FOXM1 in macrophages is required for pulmonary inflammation, recruitment of macrophages into tumor sites and lung tumor growth |
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is required for KRAS signaling in distal lung epithelium and provides a mechanism integrating Kras and canonical WNT/CTNNB1 signaling during lung development |
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is required for differentiation and maintenance of epithelial cells lining conducting airways. |
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regulates genes critical for allergen-induced lung inflammation and goblet cell metaplasia |
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is a critical regulator of the G1/S and G2/M cell cycle transitions, as well as of the mitotic spindle assembly |
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FOXM1 controls the cell cycle through its association with CDC25A |
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is required for lung fibrosis and epithelial-to-mesenchymal transition |
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promoted EMT in breast cancer cells by stimulating the transcription of EMT-related genes such as SNAI2 |
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strongly activates promoters of G2/M phase genes and weakly activates those induced in S phase |
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is an essential effector of G2/M-phase transition, mitosis and the DNA damage response |
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function for FOXM1 in interkinetic nuclear migration in the developing telencephalon and anxiety-related behavior |