| basic FUNCTION
| granule serine protease, oxygen independent phagocytosis of Gram- bacteria |
|
may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation |
|
host-derived chemotactic agonist for FPRL1 and expand the functional scope of this receptor in inflammatory and immune responses |
|
may play a role in the progression to heart failure by activating angiotensin II, leading to detrimental effects on the heart  |
|
activates F8 to a partially active form while having only a minor inactivating effect on thrombin-activated F8a |
|
it is possible that cathepsin G from neutrophils and monocytes may provide some pro-coagulant effect by activating F8 |
|
role in antigen presentation and immune-related events |
|
CTSG and ELANE are involved in the pathogenesis of a number of inflammatory disorders |
|
neutrophil-derived serine protease, inducing myocyte detachment and apoptosis by anoikis through down-regulation of focal adhesion (FA) signaling |
|
during neutrophil activation, CTSG regulates the secretion/release of multiple peptide modulators of neutrophil functions, including ANXA1 and CAMP |
|
ELANE and CTSG bind to the surface of cancer cells, presumably to a cell surface receptor, and subsequently undergo clathrin pit-mediated endocytosis |
|
neutrophil CTSG is a physiologic modulator of platelet thrombus formation |
|
importance of the cathepsin G (CTSG) in the context of arterial myeloid cell recruitment |
|
is immobilized on arterial endothelium where it activates leukocytes to firmly adhere engaging integrin clustering, a process of crucial importance to achieve effective adherence under high-shear flow |
|
may play an important role in muscle inflammatory cells infiltration by increasing the permeability of vascular endothelial cell |
