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FLASH GENE
Symbol GHSR contributors: mlc/npt - updated : 25-06-2017
HGNC name growth hormone secretagogue receptor
HGNC id 4267
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptors
    • HOMOLOGY
    interspecies homolog to C.elegans C53d5.5
    Homologene
    FAMILY
  • G protein coupled receptor family
    • CATEGORY signaling hormone , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in the pulsatile hormone release control
  • its high constitutive signaling activity is important for the function in the control of food intake and body weight
  • is an important regulator of energy and glucose homeostasis and a target for the treatment of obesity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GHSR-mediated inhibition of CACNA1A, CACNA1B attenuates GABA release in hypothalamic neurons, a mechanism that could contribute to neuronal activation through the disinhibition of postsynaptic neurons
  • LEAP2 fully inhibits GHSR activation by ghrelin and blocks the major effects of ghrelin, including food intake, GH release, and maintenance of viable glucose levels during chronic caloric restriction
  • MRAP2 altered GHSR signaling by inhibiting its constitutive activity, as well as by enhancing its G protein-dependent signaling and blocking the recruitment and signaling of ARRB in response to ghrelin
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GHIS4
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    in familial short stature (
    constitutional     --over  
    in heart failure
    constitutional     --low  
    in endometrium from women with unexplained infertility may in part explain the infertility
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS