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FLASH GENE
Symbol GHSR contributors: mlc/npt - updated : 25-06-2017
HGNC name growth hormone secretagogue receptor
HGNC id 4267
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly Homo sapiens
 pancreas   highly Homo sapiens
 thyroid   highly Homo sapiens
Nervousbraindiencephalonhypothalamus   Homo sapiens
 brainhindbraincerebellum highly Homo sapiens
Reproductivemale systemprostate    Homo sapiens
 male systemtestis  highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptors
    • HOMOLOGY
    interspecies homolog to C.elegans C53d5.5
    Homologene
    FAMILY
  • G protein coupled receptor family
    • CATEGORY signaling hormone , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in the pulsatile hormone release control
  • its high constitutive signaling activity is important for the function in the control of food intake and body weight
  • is an important regulator of energy and glucose homeostasis and a target for the treatment of obesity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GHSR-mediated inhibition of CACNA1A, CACNA1B attenuates GABA release in hypothalamic neurons, a mechanism that could contribute to neuronal activation through the disinhibition of postsynaptic neurons
  • LEAP2 fully inhibits GHSR activation by ghrelin and blocks the major effects of ghrelin, including food intake, GH release, and maintenance of viable glucose levels during chronic caloric restriction
  • MRAP2 altered GHSR signaling by inhibiting its constitutive activity, as well as by enhancing its G protein-dependent signaling and blocking the recruitment and signaling of ARRB in response to ghrelin
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GHIS4
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    in familial short stature (
    constitutional     --over  
    in heart failure
    constitutional     --low  
    in endometrium from women with unexplained infertility may in part explain the infertility
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS