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FLASH GENE

Symbol

CTSE

contributors: mct - updated : 01-06-2007

HGNC name	cathepsin E
HGNC id	2530

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function inducing a lysosomal storage disorder showing the accumulation of lysosomal membrane sialoglycoproteins (LAMP1, LAMP2, SCARB2) and the elevation of lysosomal pH in macrophages tumoral     --over   in gastric and cervical adenocarcinomas, in lung adenocarcinomas and squamous cell carcinomas, and in pancreatic ductal adenocarcinomas (Zaidi 2008)

Susceptibility

Variant & Polymorphism

Candidate gene	potential marker for the inception and progression of intestinal cancers
Marker
Therapy target

ANIMAL & CELL MODELS