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FLASH GENE
Symbol ZMYM2 contributors: mct - updated : 16-10-2017
HGNC name zinc finger, MYM-type 2
HGNC id 12989
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal cysteine-rich region comprising five tandem Cys-X2 repeats corresponding to a novel zinc finger motif
  • ten MYM, myeloproliferative and mental retardation motifs
  • a highly hydrophobic, proline-rich stretch and a putative bipartite nuclear localization signal (NLS)
    • conjugated MetalloP
    mono polymer complex
    HOMOLOGY
    interspecies homolog to murine Zfp198
    intraspecies homolog to DXS6673E,highly
    Homologene
    FAMILY
  • zinc finger protein family
  • MYM subfamily
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    basic FUNCTION
  • transcriptional regulator, involved in the DNA repair process through its interaction with UBE2A, UBE2B and RAD18
  • SUMO-binding activity of the MYM-type zinc fingers in ZMYM2 and ZMYM3
  • having multi-SUMO-binding activity required for its recruitment to chromatin
  • likely a central role for ZMYM2 in the transcriptional regulation of the undifferentiated state and in the exit-from-pluripotency of humanembryonic stem cell (ESC)
  • is a component of a transcriptional corepressor complex recently linked to the silencing of developmentally regulated endogenous retrovirus elements
  • ZMYM2 plays critical roles in kidney and craniofacial development
    • CELLULAR PROCESS nucleotide, repair
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of a histone deacetylase complex containing HDAC1, HDAC2, AOF2, RCOR1, ZNF261, KIAA0182 and GTF2I
    • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • UBE2A
  • UBE2B
  • RAD18
  • forms part of a transcriptional complex acting as a corepressor by interacting with different nuclear receptors, and the LSD1-CoREST-HDAC1 complex on chromatin
  • ZMYM2, ZMYM3, MYM-type zinc fingers interact with the same surface on SUMO-2 recognized by the archetypal consensus SIM
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SCLLS , CAKUT4S
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    ZMYM2-FGFR1 fusion in myeloproliferative syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS