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FLASH GENE

Symbol

ZMYM2

contributors: mct - updated : 16-10-2017

HGNC name	zinc finger, MYM-type 2
HGNC id	12989

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	131.70 kb     26 Exon(s)

MAPPING

cloned

Y

linked

status

confirmed

Map	cen - D13S1316 - ZMYM2 - D13S175 - GJB2 - FGF9 - D13S292 - COL4A1 - D13S283 - qter
Authors	Macdonald (99)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed - - - 5217 154.9 1377 - 2015 26283374 - - splicing 5170 154.9 1377 - 2015 26283374 NM_001353163 26 - 7424 NP_001340092 - 1290 - 2015 26283374 NM_001353157 25 - 7426 NP_001340086 - 1377 - 2015 26283374 NM_001353164 25 - 7384 NP_001340093 - 1377 - 2015 26283374 NM_001353159 25 - 7340 NP_001340088 - 1377 - 2015 26283374 NM_001190965 25 - 7547 NP_001177894 - 1377 - 2015 26283374 NM_003453 26 - 7476 NP_003444 - 1377 - 2015 26283374 NM_197968 25 - 7429 NP_932072 - 1377 - 2015 26283374 NM_001353161 27 - 7227 NP_001340090 - 1312 - 2015 26283374 NM_001353162 27 - 7587 NP_001340091 - 1377 - 2015 26283374 NM_001353165 22 - 3920 NP_001340094 - 1159 - 2015 26283374

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	stem cells

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal cysteine-rich region comprising five tandem Cys-X2 repeats corresponding to a novel zinc finger motif
	ten MYM, myeloproliferative and mental retardation motifs
	a highly hydrophobic, proline-rich stretch and a putative bipartite nuclear localization signal (NLS)

conjugated

MetalloP

mono polymer

complex

HOMOLOGY

interspecies

homolog to murine Zfp198

intraspecies

homolog to DXS6673E,highly

Homologene

FAMILY	zinc finger protein family
	MYM subfamily

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm,nuclear bodies,PML

basic FUNCTION	transcriptional regulator, involved in the DNA repair process through its interaction with UBE2A, UBE2B and RAD18
	SUMO-binding activity of the MYM-type zinc fingers in ZMYM2 and ZMYM3
	having multi-SUMO-binding activity required for its recruitment to chromatin
	likely a central role for ZMYM2 in the transcriptional regulation of the undifferentiated state and in the exit-from-pluripotency of humanembryonic stem cell (ESC)
	is a component of a transcriptional corepressor complex recently linked to the silencing of developmentally regulated endogenous retrovirus elements
	ZMYM2 plays critical roles in kidney and craniofacial development

CELLULAR PROCESS	nucleotide, repair
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

part of a histone deacetylase complex containing HDAC1, HDAC2, AOF2, RCOR1, ZNF261, KIAA0182 and GTF2I

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein	UBE2A
	UBE2B
	RAD18
	forms part of a transcriptional complex acting as a corepressor by interacting with different nuclear receptors, and the LSD1-CoREST-HDAC1 complex on chromatin
	ZMYM2, ZMYM3, MYM-type zinc fingers interact with the same surface on SUMO-2 recognized by the archetypal consensus SIM

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SCLLS , CAKUT4S

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       ZMYM2-FGFR1 fusion in myeloproliferative syndrome

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS