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FLASH GENE

Symbol

MAP2K1

contributors: mct/pgu - updated : 14-04-2017

HGNC name	mitogen-activated protein kinase kinase 1
HGNC id	6840

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

The null mutation of the mouse Mek1 gene by insertional mutagenesis was recessive lethal, and homozygous mutant embryos died at 10.5 days of gestation. Histopathologic analysis revealed a marked decrease of vascular endothelial cells in the labyrinthine region, resulting in reduced vascularization of the placenta. Failure to establish a functional placenta was considered a likely cause of embryonic death.