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| mice with a targeted disruption of Lkb1 die at midgestation, with the embryos showing neural tube defects, mesenchymal cell death and deregulation of vascular endothelial growth factor (VEGF) expression | |
Lkb1 (+/-) mice develop hamartomatous polyps in the glandular stomach |
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Lkb1(-/-) mice died in utero between 8.5 and 9.5 days postcoitum with developmental retardation and multiple gastric adenomatous polyps |
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in somatically activatable mutant Kras- driven model of mouse lung cancer, pulmonary tumorigenesis was accelerated by hemizygous inactivation of Lkb1 (STK11) |
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LKB1-deficient murine embryonic fibroblasts show nearly complete loss of Thr-172 phosphorylation and downstream AMPK signaling in response to a variety of stimuli that activate AMPK ( |
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deletion of LKB1 in liver of adult mice result in a loss of AMPK activityand hyperglycemia with increased gluconeogenic and lipogenic gene expression |
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LKB1-KO mice displayed biatrial enlargement with atrial fibrillation and cardiac dysfunction at 4 weeks of age |
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deletion of Stk11 gene in mice caused increased haematopoietic stem cell (HSC) division, rapid HSC depletion and pancytopenia ( |
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Lkb1-deficient haematopoietic stem cell have reduced mitochondrial membrane potential and ATP levels, exhibit defects in centrosomes and mitotic spindles in culture, and become aneuploid ( |
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Lkb1 inactivation in adult mice causes loss of haematopoietic stem cell quiescence followed by rapid depletion of all haematopoietic subpopulations ( |
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Lkb1-deficient bone marrow cells exhibit mitochondrial defects, alterations in lipid and nucleotide metabolism, and depletion of cellular ATP ( |
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ablation of Lkb1 in adult mice results in severe pancytopenia and subsequent lethality ( |