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FLASH GENE

Symbol

GZMB

contributors: mct/npt - updated : 21-06-2017

HGNC name	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HGNC id	4709

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   are independently associated with insulin resistance and also with increased cardiovascular (CV) risk in adolescent polycystic ovary syndrome patients constitutional       loss of function diminished the ability of a high dose of CD8(+) T cells to cause lethal graft-versus-host disease

Susceptibility

to autism spectrum disorder

Variant & Polymorphism

Candidate gene
Marker	both T2DM and central obesity were predicting factors for GZMB
Therapy target
	System Type Disorder Pubmed immunology autoimmune   inhibiting donor-derived GzmB function may represent a promising strategy to improve GVT effect without exacerbating graft-versus-host disease

ANIMAL & CELL MODELS

internalized killer cells from GzmB-deficient mice underwent a typical non-apoptotic entotic cell-in-cell death similar to that of non-cytotoxic immune cells or tumor cells