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FLASH GENE
Symbol BRD3 contributors: mct - updated : 05-07-2015
HGNC name bromodomain containing 3
HGNC id 1104
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a common domain architecture featuring two N-terminal bromodomains that exhibit high levels of sequence conservation (inhibitor JQ1 binds to the Kac binding site of BET bromodomains)
  • a PEST domain
  • one ET domain
  • a RING finger motif
  • a more divergent C-terminal recruitment domain
    • HOMOLOGY
    interspecies homolog to Drosophila female sterile homeotic gene
    homolog to murine Brd3
    intraspecies homolog to RING3
    paralog to BRD4 (54 p100)
    Homologene
    FAMILY bromodomain and extra-terminal (BET) family
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • plays a role in allowing cells to enter the proliferative phase of the angiogenic process
  • BET family members have been recognized as essential genes for the replication of viruses and in mediating inflammatory responses
  • BET family proteins recognize acetylated chromatin through their two bromodomains, acting as transcriptional activators or tethering viral genomes to the mitotic chromosomes of their host
  • recruited by GATA1 to both active and repressed target genes in a fashion seemingly independent of histone acetylation
  • "reads" acetyl marks on nuclear factors to promote their stable association with chromatin
  • BRD2, BRD3, BRD4, and BRDT are transcriptional regulators required for efficient expression of several growth promoting and antiapoptotic genes as well as for cell-cycle progression
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cofactor that interacts with acetylated GATA1 and this interaction is essential for the targeting of GATA1 to chromatin
  • binds via its first bromodomain (BD1) to GATA1 in an acetylation-dependent manner
    • cell & other
    REGULATION
    inhibited by JQ1, a selective and potent inhibitor of BET family bromodomains
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    inhibition of the BET-histone interaction results in transcriptional downregulation of a number of oncogenes, providing a novel pharmacologic strategy for the treatment of cancer
    ANIMAL & CELL MODELS