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FLASH GENE
Symbol CHD5 contributors: - updated : 11-06-2007
HGNC name chromodomain helicase DNA binding protein 5
HGNC id 16816
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a paired PHD type (C4-H-C3) zinc finger motif
  • two DNA binding chromodomains toward the N terminal
  • a central helicase ATPase related SNF2 domain
  • an helicase C-terminal domain
  • a region with similarity to the Myb-DNA binding domain
  • a DEAH box
    • conjugated HemoP
    HOMOLOGY
    interspecies homolog to chimpanzee CHD5 (98.1 pc)
    homolog to murine Chd5 (94.9 pc)
    homolog to C. elegans chd-3 (55.3 pc)
    intraspecies homolog to CHD3
    homolog to CHD4
    Homologene
    FAMILY
  • CHD family
  • chromodomain SNF2/RAD54 helicase subfamily
    • CATEGORY enzyme , regulatory , DNA associated , transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • may play a role in the development of the nervous system and the pathogenesis of neural tumors
  • acting as an ATP-dependent helicase
    • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text
  • nervous system development
    • PATHWAY
    metabolism
    signaling
    a component component of the chromatin remodeling complex
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding, nucleotide,
  • ATP
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in neuroblastoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS