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FLASH GENE

Symbol

CSHL1

contributors: - updated : 22-08-2005

HGNC name	chorionic somatomammotropin hormone-like 1
HGNC id	2442

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem, component of a cluster
text	interspersed in the same transcriptional orientation with four other related genes
STRUCTURE	1.00 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see GH@

regionally located

located at the growth hormone locus and interspersed in the same transcriptional orientation with four other related genes

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - splicing 661 - 18 - Misra-Press,MacLeod missing exon 2 utilizing the normal splice acceptor site in exon 3 lackings a signal sequence (indicating a non-secreted protein) variant 2 - splicing 376 - 23 - Misra-Press,MacLeod lacking exons 2,3 and 4 missing a signal sequence (predicting a non-secreted protein) variant 3 - splicing 837 25.4 222 - Misra-Press,MacLeod utilizing a cryptic splice donor site 19 nt into intron B and an alternative splice acceptor site 4 nt into exon 3 having six internal residues retaining the signal sequence variant 4 - splicing 588 16 139 - Misra-Press,MacLeod missing exon 2 utilizing an alternate splice acceptor site in exon 3 lacking a signal sequence variant 5 - splicing 768 22.7 199 - Misra-Press,MacLeod utilizing a cryptic splice donor site 19 nt into intron B and an alternative splice acceptor site 73 nt into exon 3 having six internal residues retaining the signal sequence

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system prostate     moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	placenta, chorion, placental villi

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

somatotropin/prolactin family of hormones

CATEGORY

regulatory , signaling hormone

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION

playing an important role in growth control

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS