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FLASH GENE

Symbol

CSH2

contributors: - updated : 12-07-2006

HGNC name	chorionic somatomammotropin hormone 2
HGNC id	2441

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem, component of a cluster
text	located at the growth hormone locus along with four other related genes in the same transcriptional orientation
STRUCTURE	1.00 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence

Promoter (TATA box)

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see GH@

regionally located

located at the growth hormone locus along with four other related genes in the same transcriptional orientation (an arrangement which is thought to have evolved by a series of gene duplications)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - splicing initiation site 883 25 217 placenta Palmetshofer utilizing all five exons variant 2 - splicing initiation site 1134 18.8 167 placenta Palmetshofer diverging in the C terminus due to a frameshift putative TM domain containing intron D variant 3 - splicing initiation site 598 13.9 122 placenta Palmetshofer retaining the signal sequence internal deletion;lacking exons 3,4 variant 4 - splicing initiation site 437 - 23 - Palmetshofer lacking exons 2,3,4 missing the signal sequence

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly Endocrine neuroendocrine pituitary     highly   thyroid       highly Hearing/Equilibrium ear       highly Reproductive female system placenta     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	placenta, chorion

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

intraspecies

paralog to GH

Homologene

FAMILY

somatotropin/prolactin family of hormones

CATEGORY

regulatory , signaling hormone

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION

playing an important role in growth control

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

hormonal

cell-cell signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

upregulated during development (isoforms 1 and 2)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS