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FLASH GENE
Symbol CSH1 contributors: - updated : 03-05-2007
HGNC name chorionic somatomammotropin hormone 1 (placental lactogen)
HGNC id 2440
Location 17q23.3-q24.2      Physical location : 61.972.272 - 61.973.987
Synonym name
  • placental lactogen
  • chorionic somatomammotropin A
    • Synonym symbol(s) PL, CSA, CSMT
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem, component of a cluster
    text located at the growth hormone locus with four other related genes in the same transcriptional orientation
    STRUCTURE 1.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see GH@
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing initiation site 879 25 217 placenta,secreted Hitchins
    - splicing initiation site 1132 28.8 256 non secreted Hitchins
  • diverging C terminus
  • putative TM domain
    • - splicing initiation site 594 13.9 122 placenta Hitchins
  • retaining the signal sequence
  • internal deletion; lacking exons 2, 3
    • - splicing initiation site 433 2.4 23 non secreted Hitchins
    lacking exons 2,3,4
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta, chorion
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    interspecies homolog to C.elegans C17B7.12
    intraspecies paralog to GH
    Homologene
    FAMILY somatotrophin/prolactin family
    CATEGORY secretory , signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION playing an important role in growth control
    CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling hormonal , signal transduction
    cell-cell signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other upregulated during development
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene hemizygosity of CSH1 in our population in comparison to controls indicates a role for CSH1 haploinsufficiency in the etiology of growth retardation
    Marker
    Therapy target
    ANIMAL & CELL MODELS