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FLASH GENE
Symbol HIST1H2AJ contributors: npt/ - updated : 12-02-2004
HGNC name histone cluster 1, H2aj
HGNC id 4727
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text E proximal cluster
STRUCTURE 0.44 kb     1 Exon(s)
regulatory sequence Promoter (CAAT box) (TATA box)
Binding site   transcription factor
text structure
  • TATA box, two OCT1 factor binding site,four CAAT boxes,a binding motif for E2F and adjacent a highly conserved octanucleotide (CACAGCTT)
  • controled by a promoter between the coding region of the two genes (H2A/H2B)
    • MAPPING cloned Y linked N status confirmed
    regionally located member of the small cluster of 16 histone genes located 2Mb centromeric to the major cluster of 35 histone genes
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 439 14 128 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
    mono polymer heteromer , octamer
    HOMOLOGY
    Homologene
    FAMILY
  • histone H2A family
    • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,nucleosome
    basic FUNCTION
  • playing a role in the compaction of DNA into nucleosomes
    • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • core histone H2A/H3B/H3/H4
    • INTERACTION
    DNA approximatively 0.146 kb
    RNA
    small molecule
    protein
  • H2A
  • H2B
  • H3
  • H4
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS