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FLASH GENE
Symbol HIST1H2AK contributors: npt/ - updated : 23-09-2004
HGNC name histone cluster 1, H2ak
HGNC id 4726
Location 6p21.3      Physical location : 27.805.658 - 27.806.117
Synonym name
  • H2A histone family, member D
  • histone 1, H2ak
    • Synonym symbol(s) H2A/d, H2AFD, HIST1H2AI, H2AFC, H2AFD, H2AFI, H2AFN, H2AFAP
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text D proximal cluster
    STRUCTURE 0.50 kb     1 Exon(s)
    regulatory sequence Promoter (CAAT box) (TATA box)
    text structure
  • TATA box,two OCT1 factor binding site, four CAAT boxes,binding motif for E2F and adjacent a highly conserved octanucleotide (CACAGCTT)
  • controled by a promoter between the coding region of the two genes (H2A/H2B)
    • MAPPING cloned Y linked N status confirmed
    regionally located . member of the small cluster of 16 histone genes located 2Mb centromeric to the major cluster of 35 histone genes
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 460 14 130 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary   
    Lymphoid/Immunelymph node    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    mono polymer heteromer , octamer
    HOMOLOGY
    Homologene
    FAMILY
  • histone H2A family
    • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,nucleosome
    basic FUNCTION
  • playing a role in the compaction of DNA into nucleosomes
    • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • core histone H2A/H3B/H3/H4
    • INTERACTION
    DNA approximatively 0.146 kb
    RNA
    small molecule
    protein
  • H2A
  • H2B
  • H3
  • H4
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS