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FLASH GENE
Symbol CEP170 contributors: mct - updated : 27-04-2014
HGNC name centrosomal protein 170kDa
HGNC id 28920
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one LISH domain
conjugated PhosphoP
HOMOLOGY
interspecies homolog to Xenopus APC
ortholog to murine Cep170
Homologene
FAMILY forkhead-associated (FHA) family
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
text
  • associates with centrosomes during interphase and with spindle microtubules during mitosis
    • basic FUNCTION
  • may be playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus
  • ZBTB18 is implicated with CEP170 as novel genes causative for corpus callosal abnormalities in patients with a terminal 1q deletion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DKC1
  • fibrillarin
  • physiological substrate of PLK1 )
  • binding partner of WDR62, which is of interest given the involvement of other centrosomal proteins in microcephaly
  • CEP170 and CEP170B (KIAA0284) are specifically associating with KIF2B
  • TBK1 binds to the centrosomal protein CEP170 and to the mitotic apparatus protein NUMA1, and both CEP170 and NUMA1 are TBK1 substrates
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • marker for maternal centrioles important to elucidate the pathogenesis of numerical centriole aberrations in tumor cells
    • Therapy target
    ANIMAL & CELL MODELS