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FLASH GENE
Symbol PREPL contributors: mct - updated : 09-01-2024
HGNC name prolyl endopeptidase-like
HGNC id 30228
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer monomer
HOMOLOGY
interspecies homolog to moraxella proteinase 2
intraspecies homolog to prolyl endopeptidase and oligopeptidase B
homolog to PREP
Homologene
FAMILY
  • peptidase S9A family
  • prolyl peptidase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION serine peptidase cleaving peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long
  • may also have biological functions independent of its predicted peptidase activity
  • PREPL specifically impacts Complex IV biogenesis by acting at the intersection of mitochondrial lipid metabolism and protein synthesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HCYS , PREPLDI
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Prepl(-/-) mice suffer from neonatal hypotonia