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FLASH GENE
Symbol PREPL contributors: mlc - updated : 26-10-2007
HGNC name prolyl endopeptidase-like
HGNC id 30228
Corresponding disease
HCYS hypotonia-cystinuria syndrome
Location 2p22.1-p21      Physical location : 44.544.749 - 44.589.001
Genatlas name related to moraxella proteinase 2, 72kDa
Synonym name
  • putative L-type neutral aminoacid transporter
  • putative prolyl oligopeptidase
    • Synonym symbol(s) FLJ16627, KIAA0436
    DNA
    TYPE functioning gene
    STRUCTURE 43.00 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map pter - LRPPRC - SLC3A1 - PREPL - C2orf34 - SIX3 - cen
    Authors Martens (2007)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4636 - 665 - Martens (2006)
    - - 4624 - 661 - Martens
    - - 4822 - 727 - Martens
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousbrain   highly
    Urinarykidney   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to moraxella proteinase 2
    intraspecies homolog to prolyl endopeptidase and oligopeptidase B
    Homologene
    FAMILY peptidase S9A family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION serine peptidase cleaving peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HCYS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS