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FLASH GENE

Symbol

SRGAP3

contributors: mct/npt - updated : 23-02-2016

HGNC name	SLIT-ROBO Rho GTPase activating protein 3
HGNC id	19744

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus         Nervous brain diencephalon hypothalamus   highly   brain forebrain cerebral cortex     Reproductive female system ovary         male system prostate         male system testis       Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid         Nervous central       Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal FCH, and F-BAR(3) inducing filopodia in both cell types, though less potently than F-BAR(SRGAP2) , and F-BAR localizes SRGAP3 to the leading edge of cellular protrusions
	a central RHO-GAP
	a FBH and a SH3 domains, important for focal adhesion targeting
	a single PXXP motif in the C-terminal region of SRGAP3 mediates binding to multiple SH3 domains

HOMOLOGY

intraspecies

homolog to RHO-GAP hematopoietic protein C1(ARHGAP4)

Homologene

FAMILY	Rho GTPases family
	FNBP2 family
	Slit-Robo GAP (srGAP) family

CATEGORY

regulatory , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	undergoes regulated shuttling between the cytoplasm and the nucleus during neuronal development
	RAPH1 localizes with SRGAP3 at the leading edge

basic FUNCTION	involved in axon guidance and neurite outgrowth and in mental development
	SRGAP, SRGAP2, SRGAP3 are not only involved in the regulation of the Slit-Robo signal transduction, but also in neuronal development and that the translocation of srGAPs is important for their functions
	implicated in repulsive axon guidance and neuronal migration through Slit-Robo-mediated signal transduction
	inhibitory role of SRGAP3 on actin dynamics, specifically on lamellipodia formation
	controls actin and microtubule dynamics through negative regulation of RAC1
	has tumor suppressor-like activity in mammary epithelial cells, likely through its activity as a negative regulator of RAC1
	SRGAP3-mediated cytoskeletal reorganisation has an important influence on a variety of neurodevelopmental processes, which may be required for normal cognitive function
	important modulator of actin cytoskeletal dynamics and has an important influence on a variety of neurodevelopmental processe
	implicated in different critical aspects of neuronal development
	via its interactions SRGAP3 could link receptor signalling events to the endocytic machinery

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

signal transduction

a component

component of the WAVE1 complex

INTERACTION

DNA

RNA

small molecule

protein	interacting with the intracellular domain of ROBO1
	binding partner of WASF1/WAVE1 that funtions as a signal termination factor for Rac
	SRGAP3 influences RAPH1-evoked lamellipodial dynamics
	interplay between SRGAP1, SRGAP2 and SRGAP3 regulates neuronal differentiation and neurite outgrowth
	nuclear-localized SRGAP3 interacts with the SWI/SNF remodeling factor sMARCA4

cell & other

REGULATION

activated by

enhanced by SLIT*

Other

inactivated by CDC42

ASSOCIATED DISORDERS

corresponding disease(s)

MRAJ , DEL3PD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       in-frame oncogenic fusion between SRGAP3 and RAF1 in Pilocytic astrocytomas (Jones 2009)

Susceptibility

Variant & Polymorphism

Candidate gene	for MR in 3p deletion
Marker
Therapy target

ANIMAL & CELL MODELS