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FLASH GENE
Symbol GAS7 contributors: mct/npt - updated : 17-02-2010
HGNC name growth arrest-specific 7
HGNC id 4169
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one WW domain
  • one FCH domain
  • F-BAR domain, which mediates oligomer formation and interactions with the submembrane region (You 2010)
  • C-terminal domains with the coiled-coil domain are essential for the submembrane localization that is required for GAS7-induced membrane protrusion formation (You 2010)
    • HOMOLOGY
    interspecies ortholog to murine Gas7
    homolog to Drosophila ade3
    homolog to C.elegans f38b6.4
    Homologene
    FAMILY
  • PCH (Pombe Cdc15 homology) protein family, PSTPIP subfamily
    • CATEGORY adaptor , transcription factor , protooncogene , signaling growth factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in neurite formation
  • may play a role in promoting maturation and morphological differentiation of cerebellar neurons
  • playing a role in modulating neurotransmitter release
  • having an essential role through its interaction with WASL during neuronal maturation/differentiation (You 2010)
  • may be involved in neurite outgrowth through WASL-mediated actin organization in hippocampal neurons (You 2010)
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    text neuronal development, cell cycle arrest
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with F-actin and colocalizes with the terminal part of actin microfilament in cells in which membrane outgrowth is present
  • interaction between GAS7 and WASL is mediated by WW-Pro domains, which is unique in the PCH protein family, where most interactions are of the SH3-Pro kind (You 2010)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    translocation t(11;17)(q23;p13) with fusion MLL-GAS7 in acute myeloid leukemia
    constitutional       loss of function
    may be a key executive process to accelerate cellular dysfunction and death in the Tau pathology of Alzheimer disease (Akiyama 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS