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FLASH GENE

Symbol

GAS7

contributors: mct/npt - updated : 17-02-2010

HGNC name	growth arrest-specific 7
HGNC id	4169

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Cardiovascular heart         Digestive intestine small intestine       Nervous brain hindbrain cerebellum cerebellar cortex highly   brain diencephalon hypothalamus   highly   brain limbic system hippocampus   predominantly Reproductive male system prostate     lowly Respiratory respiratory tract trachea     highly Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective         Lymphoid         Nervous central       Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol   digestive Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one WW domain
	one FCH domain
	F-BAR domain, which mediates oligomer formation and interactions with the submembrane region (You 2010)
	C-terminal domains with the coiled-coil domain are essential for the submembrane localization that is required for GAS7-induced membrane protrusion formation (You 2010)

HOMOLOGY

interspecies	ortholog to murine Gas7
	homolog to Drosophila ade3
	homolog to C.elegans f38b6.4

Homologene

FAMILY

PCH (Pombe Cdc15 homology) protein family, PSTPIP subfamily

CATEGORY

adaptor , transcription factor , protooncogene , signaling growth factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	involved in neurite formation
	may play a role in promoting maturation and morphological differentiation of cerebellar neurons
	playing a role in modulating neurotransmitter release
	having an essential role through its interaction with WASL during neuronal maturation/differentiation (You 2010)
	may be involved in neurite outgrowth through WASL-mediated actin organization in hippocampal neurons (You 2010)

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

development

text	neuronal development, cell cycle arrest

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts with F-actin and colocalizes with the terminal part of actin microfilament in cells in which membrane outgrowth is present
	interaction between GAS7 and WASL is mediated by WW-Pro domains, which is unique in the PCH protein family, where most interactions are of the SH3-Pro kind (You 2010)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     translocation t(11;17)(q23;p13) with fusion MLL-GAS7 in acute myeloid leukemia constitutional       loss of function may be a key executive process to accelerate cellular dysfunction and death in the Tau pathology of Alzheimer disease (Akiyama 2009)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS